Exploring Crohn’s disease and ulcerative colitis through systems-level biology

Inflammatory Bowel Disease (IBD), including Crohn’s disease and ulcerative colitis, is a chronic and heterogeneous condition driven by complex interactions between immune regulation, genetics, environment, and tissue-specific biology.

Mavatar Discovery supports IBD research by enabling structured, data-driven exploration of disease mechanisms across tissues, disease subtypes, and inflammatory contexts - helping researchers better understand biological variation within and across IBD subtypes.

The Challenge

Why IBD Research Is Complex

IBD research is often constrained by:

- Strong biological heterogeneity between patients

- Overlapping yet distinct mechanisms in Crohn’s disease and ulcerative colitis

- Fragmented transcriptomic data across tissues, cohorts, and disease stages

- Difficulty translating molecular findings into precision medicine insight

As a result, researchers frequently spend months identifying relevant data and it’s integration before meaningful biological interpretation can begin.

Mavatar Discovery

A Data-Driven Approach to IBD Research

Our Mavatar Discovery platform integrates peer-reviewed transcriptomic datasets across IBD-related tissues, disease stages, and experimental contexts into a single, structured research environment.

Instead of analyzing datasets in isolation, researchers explore integrated biological networks that reveal coordinated gene activity and pathway interactions across Crohn’s disease and ulcerative colitis - supporting reproducible, systems-level exploration of IBD biology.

How Mavatar Discovery Supports IBD Research

Explore disease-specific biological networks
Investigate gene networks specific to Crohn’s disease and ulcerative colitis, moving beyond isolated genes to understand coordinated biological processes.

Identify molecular patterns linked to disease activity
Explore pathway-level patterns associated with inflammation and disease-relevant biological processes.

Investigate tissue- and context-specific biology
Analyze transcriptomic variation across intestinal regions, and immune compartments to understand where biological changes occur.

Support exploratory research into treatment contexts
Enable exploratory analysis of molecular patterns associated with different treatment settings to support hypothesis generation in IBD research.

Value Created:

For Academic & Translational Researchers

Faster hypothesis generation

Deeper understanding of IBD heterogeneity

Stronger pilot data for grants and collaborations

Higher reproducibility of findings

For Pharma & R&D Teams

Earlier insight into disease biology

Improved exploration of targets and biomarkers

Reduced early-stage uncertainty

Scalable, consistent analysis across programs

IBD Research at Mavatar

Precision Medicine in IBD - A National Collaboration

Mavatar contributes to the Vinnova-funded project “Precision Medicine in Inflammatory Bowel Disease (IBD)”, a national initiative led by RISE together with academic, clinical, and industry partners.

As part of this collaboration, Mavatar has delivered integrated IBD transcriptomic resources and disease-specific biological networks for Crohn’s disease and ulcerative colitis - developed in close collaboration with pharma, academia, and healthcare to align with real-world research needs.

👉 Learn more about our IBD collaboration